SrasV1, Main, Exploration, bibRecord, 004D85

Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus

Identifieur interne : 004D85 ( Main/Exploration ); précédent : 004D84; suivant : 004D86

Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus

Auteurs : Sara Akerström [Suède] ; Mehrdad Mousavi-Jazi [Suède] ; Jonas Klingström [Suède] ; Mikael Leijon [Suède] ; Ake Lundkvist [Suède] ; Ali Mirazimi [Suède]

Source :

Journal of virology [ 0022-538X ] ; 2005.

RBID : Pascal:05-0134586

Descripteurs français

KwdFr :
- Animaux, Cellules Vero, Humains, Monoxyde d'azote (métabolisme), Monoxyde d'azote (pharmacologie), N-Acétyl-S-nitroso-pénicillamine (pharmacologie), Nitric oxide synthase (métabolisme), Nitric oxide synthase type II, Réplication virale (), Virus du SRAS (), Virus du SRAS (physiologie).
MESH :
- métabolisme : Monoxyde d'azote, Nitric oxide synthase.
- pharmacologie : Monoxyde d'azote, N-Acétyl-S-nitroso-pénicillamine.
- physiologie : Virus du SRAS.
Pascal (Inist)
- Animaux, Cellules Vero, Coronavirus, Azote monoxyde, Humains, Nitric oxide synthase type II, Réplication, Microbiologie, Réplication virale, Virologie, Syndrome respiratoire aigu sévère, Virus du SRAS.

English descriptors

KwdEn :
- Animals, Chlorocebus aethiops, Coronavirus, Humans, Microbiology, Nitric Oxide (metabolism), Nitric Oxide (pharmacology), Nitric Oxide Synthase (metabolism), Nitric Oxide Synthase Type II, Nitric oxide, Replication, S-Nitroso-N-Acetylpenicillamine (pharmacology), SARS Virus (drug effects), SARS Virus (physiology), Severe acute respiratory syndrome, Vero Cells, Virology, Virus Replication (drug effects).
MESH :
- chemical , metabolism : Nitric Oxide, Nitric Oxide Synthase.
- chemical , pharmacology : Nitric Oxide, S-Nitroso-N-Acetylpenicillamine.
- drug effects : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Humans, Nitric Oxide Synthase Type II, Vero Cells.

Abstract

Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.

Affiliations:

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<term>Microbiology</term>
<term>Nitric Oxide (metabolism)</term>
<term>Nitric Oxide (pharmacology)</term>
<term>Nitric Oxide Synthase (metabolism)</term>
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<term>Virus du SRAS ()</term>
<term>Virus du SRAS (physiologie)</term>
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<term>Nitric Oxide Synthase</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Nitric Oxide</term>
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<front><div type="abstract" xml:lang="en">Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.</div>
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Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus

Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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